- Title
- Patterns and risk factors for locoregional failures after mastectomy for breast cancer: an international breast cancer study group report
- Creator
- Karlsson, P.; Cole, B. F.; Forbes, J. F.; Gelber, R. D.; Goldhirsch, A.; Gruber, G.; Chua, B. H.; Price, K. N.; Lindtner, J.; Collins, J. P.; Kovacs, A.; Thurlimann, B.; Crivellari, D.; Castiglione-Gertsch, M.
- Relation
- Annals of Oncology Vol. 23, Issue 11, p. 2852-2858
- Publisher Link
- http://dx.doi.org/10.1093/annonc/mds118
- Publisher
- Oxford University Press
- Resource Type
- journal article
- Date
- 2012
- Description
- Background: Rates and risk factors of local, axillary and supraclavicular recurrences can guide patient selection and target for postmastectomy radiotherapy (PMRT). Patients and methods: Local, axillary and supraclavicular recurrences were evaluated in 8106 patients enrolled in 13 randomized trials. Patients received chemotherapy and/or endocrine therapy and mastectomy without radiotherapy. Median follow-up was 15.2 years. Results: Ten-year cumulative incidence for chest wall recurrence of >15% was seen in patients aged <40 years (16.1%), with ≥4 positive nodes (16.5%) or 0–7 uninvolved nodes (15.1%); for supraclavicular failures >10%: ≥4 positive nodes (10.2%); for axillary failures of >5%: aged <40 years (5.1%), unknown primary tumor size (5.2%), 0–7 uninvolved nodes (5.2%). In patients with 1–3 positive nodes, 10-year cumulative incidence for chest wall recurrence of >15% were age <40, peritumoral vessel invasion or 0–7 uninvolved nodes. Age, number of positive nodes and number of uninvolved nodes were significant parameters for each locoregional relapse site. Conclusion: PMRT to the chest wall and supraclavicular fossa is supported in patients with ≥4 positive nodes. With 1–3 positive nodes, chest wall PMRT may be considered in patients aged <40 years, with 0–7 uninvolved nodes or with vascular invasion. The findings do not support PMRT to the dissected axilla.
- Subject
- adjuvant treatment; breast cancer; locoregional recurrence; postmastectomy radiotherapy
- Identifier
- http://hdl.handle.net/1959.13/1307470
- Identifier
- uon:21434
- Identifier
- ISSN:0923-7534
- Language
- eng
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